Fullmetal Alchemist is a Japanese manga series written and illustrated by Hiromu Arakawa. It was serialized in Square Enix's Monthly Shōnen Gangan shōnen manga anthology magazine between July 2001 and June 2010; the publisher later collected the individual chapters into twenty-seven tankōbon volumes. The steampunk world of Fullmetal Alchemist is primarily styled after the European Industrial Revolution. Set in the early 20th century, in a fictional universe in which alchemy is a widely practiced science, the series follows the journey of two alchemist brothers, Edward and Alphonse Elric, who are searching for the philosopher's stone to restore their bodies after a failed attempt to bring their mother back to life using alchemy.

The series received an anime adaptation in 2003 that featured significant divergences from the plot, including original characters and altered designs for some characters. e621 does not currently make distinctions between these two canons.