In the Mass_effect game universe, Biotics, or biotic ability, originates from exposure to dust-form element zero (colloquially known as "eezo") in utero, which can subsequently develop eezo nodules throughout the nervous system. These nodules can generate mass effect fields when energized by electrical impulses from the brain.

Biotic abilities fall into three general categories: Tekinesis, the use of mass-lowering fields to lift or hurl objects, Kinetic Fields, mass-raising fields to immobilize objects (in combat, usually enemy projectiles or enemies themselves), and Spatial Distortion, the creation of shifting mass-effect fields which rip apart any objects caught within them.

It is noteable that all asari are naturally biotic from birth, due to the high concentration of element zero found on Thessia, the Asari homeworld.