Jessica Rabbit is Roger Rabbit's human Toon wife and the tritagonist in Disney/Touchstone's 1988 hybrid film Who Framed Roger Rabbit. In the book, she was an amoral up-and-coming star and former comic character, over whom her estranged husband, comic strip star Roger Rabbit, obsessed. She is re-imagined in the film as a sultry, but moral cartoon singer at a Los Angeles supper club called the "Ink and Paint Club". Here, she is one of several suspects in the framing of her husband, who is a famous cartoon star. She is voiced by Kathleen Turner, while Amy Irving was cast to sing Peggy Lee’s "Why Don't You Do Right" for Jessica's first scene in the film.

Several attractive Toon females (specifically Betty Boop) apparently consider Jessica to be incredibly lucky to be married to Roger.

Jessica attests to Eddie Valiant that "I'm not bad, I'm just drawn that way." Indeed, Jessica proves herself to be selfless and compassionate throughout the movie. Although she seems to be cool and distant on the surface, Jessica has a soft spot for her husband Roger, whom she married because he "made her laugh". She adores him beyond measure and is irrefutably loyal towards him. She makes it clear that despite what others think of her, she only has eyes for Roger and would do absolutely anything for his sake. Jessica proves herself to be brave, quick-witted and intuitive; she knowingly puts herself at risk to save Roger and Eddie. Yet despite the dangers, she always maintains a calm composure and exhibits great skill in combat, including handling a gun.

Jessica is a tall, beautiful, and voluptuous woman. She has a curvy and slender hourglass figure with a narrow waist, buxom bosom and broad hips. She has fair skin and long, luxurious deep-red hair with sidebangs that cover her right eye. Her light green eyes are heavy-lidded and seductive with long dark lashes and accented by a shimmering purple eyeshadow. Jessica's nose is fairly small, especially in relation to her large, red pouting lips.

Jessica's ensemble consists of a red, sequined strapless dress with a low back, sweetheart neckline, and high thigh slit. In addition, she wears matching red pumps, elegant purple opera gloves, and gold stud earrings.