Ōkami (大神, Ōkami? lit. "Great God", though also a pun for "wolf") is an action-adventure video game developed by Clover Studio and distributed by Capcom for the PS2 and the Wii.
In this game the player controls Ōkami Amaterasu, the goddess of the sun, in the form of a white wolf. While Amaterasu is referred to in the Japanese and European version of the game as a female, the North American version never states Amaterasu as a specific sex. Some characters, however, will refer to Amaterasu in either a feminine or masculine method, but neither are shown to be correct or incorrect.
The game featuring not only a goddess in wolf form as the main character, but an entire race of people who can shapeshift into wolves. (If you have the game, paint Bloom around any of the Wep'keer tribe and get a surprise)